Hilary Arnold Godwin, Associate Professor
Depts. of Chemistry, Biochemistry, Molecular Biology and Cell Biology
Northwestern University

E-mail: h-godwin@northwestern.edu
Phone: 847-467-3543

BS, University of Chicago (1989)
PhD, Stanford University (1994)

Paul Saltman Award (2001)
Camille Dreyfus Teacher-Scholar Award (2000)
Sloan Research Fellowship (2000)
National Science Foundation CAREER Award (1999)
Burroughs Wellcome Fund Toxicology New Investigator Award (1998)
Member, Lurie Cancer Center, Northwestern University (1997- )
Preceptor, Interdepartmental Biological Sciences Program, Northwestern University (1996- )
Camille and Henry Dreyfus New Faculty Award (1996)
National Institutes of Health Postdoctoral Research Fellowship (1994-96)
Stanford Centennial Teaching Assistant Award (1992)
National Science Foundation Graduate Research Fellowship (1989-92)

Research Areas
The research in the Godwin laboratory focuses on elucidating the molecular mechanisms of neurological and hormonal signaling, how native metals (e.g., Ca2+ and Zn2+) regulate signal transduction, and how toxic metals (e.g., Pb2+) affect these processes. Work in the NSEC focuses on developing new technologies for studying biological signaling both in vitro and in vivo. Towards this end, this group collaborates with the Van Duyne group to develop new methods to selectively conjugate proteins to glass slides, novel ways to monitor gene expression in real time, and new approaches to promote the uptake of nanoparticles into cells.

Related Publications
"Synaptotagmin I is a Molecular Target for Lead," C.M.L.S. Bouton, L.P. Frelin, C.E. Forde, H.A. Godwin, J. Pevsner, J. Neurochem., 76, 1724-1735 (2001).

"Calcium Triggers An Intramolecular Association Between The C2 Domains Of Synaptotagmin," R.A. Garcia, C.A. Forde, H.A. Godwin, Proc. Natl. Acad. Sci. U.S.A., 97, 5883-5888 (2000).

"A Selective, Ratiometric, Fluorescent Sensor for Pb2+", S. Deo, H.A. Godwin, J. Am. Chem. Soc., 122, 174-175 (2000).

"Lead-Fingers: Pb(II)-Binding to Structural Zinc-Binding Domains Determined Directly By Monitoring Lead-Thiolate Charge Transfer Bands," J.C. Payne, M.A. ter Horst, H.A. Godwin, J. Am. Chem. Soc., 121, 6850-6855 (1999).